A suite of engineered mice for interrogating psychedelic drug actions #psychedelics Congrats to Yi-ting, Ariel, Bill, Gavin, Dewran, Pierre and too many others to mention. A yuuge effort and we hope that folks will find these mice useful nature.com/articles/s41593-0…

Very sad to hear about the passing of Boris Tabakoff. Boris had an incredible career and influence in the alcohol research field. We've had an ongoing collaboration for over a decade and I always enjoyed our discussions and was looking forward to our lunches at RSA and SFN. You will be missed by many, rest in peace Boris. millerfhed.com/obituaries/dr…

Synthetic coolants may increase the abuse liability of nicotine-containing e-cigarettes nature.com/articles/s41386-0…

Michael Levin kills me. Because there's an interesting observation here (that maybe you can bias cortical cultures to grow in a certain direction), confounded by the lack of an effective control (checking to see if you can bias cortical cultures to grow in any other direction or if you've just made them always go left no matter what), completely muddled by some nonsense theory (something about "training cells out of disease states"). All of his papers are like this. An interesting, usually unreproducible observation; zero interest in effective controls or interrogating whether it's a robust phenomenon; a lot of handwaving on top.

This does not mean they are devoid of side effects. Hppd is real as is psychosis. Both apparently relatively rare but if it happens to you or a loved one little solace.

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation elifesciences.org/articles/1…

The VA has picked ten sites for the first approved psychedelic therapies. A senior VHA adviser at Horizons: it’ll be “a challenge in the first year to treat four digits’ worth of patients.” About 2.1 million veterans in VA care have PTSD or depression. This week’s psychedelic policy briefing ↓

"...psychedelic-related psychosis, although rare, represents a clinically relevant phenomenon, particularly among individuals with identifiable vulnerabilities.." journals.sagepub.com/doi/10.…

Neural circuitry mediating hypercapnia-induced microarousal and impaired sleep depth | Science Advances science.org/doi/10.1126/scia…

mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells | PNAS pnas.org/doi/10.1073/pnas.26…

“Evil is whatever distracts.” - Nietzsche

WOW!! Single Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression jamanetwork.com/journals/jam…

“It does not matter if you are a rose or a lotus or a marigold. What matters is that you are flowering.” ~ Osho

“Within the spiritual journey, you understand that suffering becomes something that has been given to you to show you where your mind is still stuck”. ~ Ram Dass

Kevan Shokat (@kevansf) made KRAS druggable. With daraxonrasib now in the clinic, he is “all in” on the ultimate target: p53 Shokat was named 2026 Stephenson Global Prize winner cancerletter.com/conversatio…

Watch Supplementary Video 4 🔥 I still remember @DR_WANG_SIBCB showed this video at the Psychedelics GRC and it drew an audible gasp from the audience

Considering the endless list of factors required for anything to happen, one can only admit that everything is responsible for everything, however remote. Doership is a myth born from the illusion of ‘me’ and ‘the mine’

Sadly I'm going to miss this important conference....