Jason Fish@FishLab_UHN

Vascular biologist at University Health Network

 Toronto, Canada
uhnresearch.ca/researcher/ja…
Joined June 2020
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Jason Fish retweeted
Anthony Gramolini@A_Gramolini
Oct 5
1/2 Very proud of Omar Hamed & the entire team! Our new @NatureCVR paper is out, with a terrific News & Views by @AliciaLundby. Fantastic, longstanding collaboration with @FilioBillia and a huge group effort! nature.com/articles/s44161-0… #HeartFailure #Proteomics
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Jason Fish retweeted
Milica Radisic@milicaruoft
Oct 5
More about the heart's hidden shield against cancer nature.com/articles/s41467-0… @AmidShakeri @NatureComms @FishLab_UHN @UHN_Research
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8 years of work. Finally published. Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1. Grateful to everyone who made this journey possible. @UHN @UofT_LMP 🔗 ahajournals.org/doi/10.1161/… #atherosclerosis

Arterial Resident But Not Monocyte-Derived Macrophages Require Endothelial CSF1 | Circulation...

BACKGROUND: Tissue-resident macrophages (T-RMøs) accumulate at sites predisposed to atherosclerosis in the healthy aortic intima. T-RMøs require local cues for their maintenance, but the niche...

ahajournals.org
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1/5 What if an existing rheumatoid arthritis drug could help target the plaque biology that drives heart disease, not just cholesterol? Using a human arterial-wall gene network and NIH LINCS drug data, we identified auranofin as a top candidate for atherosclerosis.
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Jason Fish retweeted
UHN Research@UHN_Research
Sep 4
New research from @UHN’s @PMunkCardiacCtr shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries. 🔗: uhnresearch.ca/news/9-04-202…
Illustration of a heart beside a cross-section of an artery narrowed by plaque buildup, with red blood cells flowing through the vessel, depicting cardiovascular disease.

ALT Illustration of a heart beside a cross-section of an artery narrowed by plaque buildup, with red blood cells flowing through the vessel, depicting cardiovascular disease.

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Jason Fish retweeted
Kathryn Howe@kat_howe
Aug 25
Reposting - our new story - now available for all! Open access. nature.com/articles/s41467-0… Thank you @NatureComms for the incredible editorial work and review process. Hard work that led to a transformative paper! Congrats team @SRBotts @kat_howe @FishLab_UHN

ERG preserves endothelial identity to limit atherosclerosis

Nature Communications - Endothelial cell function protects against atherosclerosis, but how loss of endothelial identity contributes to disease progression remains unclear. Here, the authors show...

nature.com
Steven Botts@SRBotts
Jul 13
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression? Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7 @kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
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Jason Fish retweeted
Kai Wang@KaiWang_PKU
Aug 13
Glad to share our recent paper published @ScienceAdvances ETV2 is the initiator of the offense, and TAL1 is the setter; together they sweep through the field, and neither can be missed. What's even more intriguing is that its function is not entirely conserved across species.
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Replying to @husam247 @CIHR_IRSC @WCHospital @PMunkCardiacCtr @uoftmedicine
Congrats!
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Jason Fish retweeted
Steven Botts@SRBotts
Jul 13
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression? Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7 @kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
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Jason Fish retweeted
Steven Botts@SRBotts
May 1
Very excited to share chapter 1 of our endothelial identity story out now in @GenomeMedicine !! Here we show that ERG governs dynamic and reversible EndMT in arterial ECs to limit endothelial dysfunction: link.springer.com/article/10… @FishLab_UHN @kat_howe @Kristen_ESchulz

ERG is a regulator of dynamic and reversible endothelial plasticity

Genome Medicine - Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal...

link.springer.com
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