Vascular biologist at University Health Network
Toronto, Canada
- Tweets 589
- Following 508
- Followers 871
- Likes 1,225
Jason Fish retweeted
1/2
Very proud of Omar Hamed & the entire team! Our new @NatureCVR paper is out, with a terrific News & Views by @AliciaLundby.
Fantastic, longstanding collaboration with @FilioBillia and a huge group effort!
nature.com/articles/s44161-0…
#HeartFailure #Proteomics
1
6
10
1,488
Jason Fish retweeted
More about the heart's hidden shield against cancer nature.com/articles/s41467-0… @AmidShakeri @NatureComms @FishLab_UHN @UHN_Research
9
36
3,325
Jason Fish retweeted
8 years of work. Finally published.
Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1.
Grateful to everyone who made this journey possible. @UHN @UofT_LMP
🔗 ahajournals.org/doi/10.1161/…
#atherosclerosis
7
3
8
628
Jason Fish retweeted
1/5 What if an existing rheumatoid arthritis drug could help target the plaque biology that drives heart disease, not just cholesterol?
Using a human arterial-wall gene network and NIH LINCS drug data, we identified auranofin as a top candidate for atherosclerosis.
3
3
4
334
Jason Fish retweeted
New research from @UHN’s @PMunkCardiacCtr shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries.
🔗: uhnresearch.ca/news/9-04-202…
ALT Illustration of a heart beside a cross-section of an artery narrowed by plaque buildup, with red blood cells flowing through the vessel, depicting cardiovascular disease.
1
5
9
875
Jason Fish retweeted
Reposting - our new story - now available for all! Open access. nature.com/articles/s41467-0… Thank you @NatureComms for the incredible editorial work and review process. Hard work that led to a transformative paper! Congrats team @SRBotts @kat_howe @FishLab_UHN
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?
Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7
@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
3
9
23
3,863
Jason Fish retweeted
Glad to share our recent paper published
@ScienceAdvances
ETV2 is the initiator of the offense, and TAL1 is the setter; together they sweep through the field, and neither can be missed. What's even more intriguing is that its function is not entirely conserved across species.
1
1
4
154
Jason Fish retweeted
#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?
Thrilled to share my final PhD work in @NatureComms: bit.ly/4fxmpl7
@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular
3
6
26
7,098
Jason Fish retweeted
Very excited to share chapter 1 of our endothelial identity story out now in @GenomeMedicine !!
Here we show that ERG governs dynamic and reversible EndMT in arterial ECs to limit endothelial dysfunction: link.springer.com/article/10…
@FishLab_UHN @kat_howe @Kristen_ESchulz
2
8
16
1,668
Very excited about this study in @EmboMolMed, where we show that KRAS mutations drive glycolytic reprogramming of the endothelium in sporadic brain arteriovenous malformations. We show a synergistic impact of targeting glycolysis and MEK. link.springer.com/article/10…
2
3
10
605
Work was led by Ruilin Wu with collaboration with Negar Khosraviani, Ann Mansur, Kathryn Howe, Ivan Radovanovic, Josh Wythe and many others. @UHN
3
129
Jason Fish retweeted
Thank you @kat_howe and @FishLab_UHN !! It was an absolute pleasure completing this journey with your guidance and support. Very excited to share our research story in the days ahead!
A celebratory moment for Dr Steven Botts. Newly minted PhD! Congrats @SRBotts - you are an asset to every team you join. Our lab has been enriched by you. Looking forward to showcasing your exciting work!
1
11
969
Jason Fish retweeted
#CTRCD may be identifiable before therapy begins. In #HER2+ #breastCA pretreatment endothelial & inflammatory biomarkers: ANGPT2, MPO, & endoglin, outperformed clinical & CMR in predicting cardiac dysfunction jacc.org/doi/10.1016/j.jacca…
#JACCCardioOnc #BCsm @dineshpmcc1 @FishLab_UHN
1
2
12
2,483
Jason Fish retweeted
Yep 👇this is what it’s all about! Come work with us at howeandfishlabs.com @FishLab_UHN @kat_howe So many great endothelial centric stories. Keen on vascular biology? Cool cellular communication? Cell identity? Novel therapeutic strategies? 😎UHN Canada Leads filling fast!
UHN's bold Canada Leads initiative aims to attract top US researchers amid funding cuts, creating a unique opportunity to recruit global talent. With a vision to elevate excellence, Toronto is set to be a leading hub for scientific innovation.
Read more: bit.ly/44h1hsS
8
11
2,955
Jason Fish retweeted
Exciting work by @FishLab_UHN using #cardioncology cohorts @PMunkCardiacCtr / combined blood biomarkers approach to predict #CTRCD @JACCJournals even before cancer therapy. Reach out if u have banked blood for additional external validation.@ICOSociety @CCardiacON @UHN @UofT
Excited to share our paper jacc.org/doi/10.1016/j.jacca…. Together with @dineshpmcc1 and led by Dakota Gustafson and Priya Mistry, we show that elevated levels of inflammatory and endothelial activation biomarkers before treatment can predict cancer therapy-related cardiac dysfunction.
2
12
1,533
Excited to share our paper jacc.org/doi/10.1016/j.jacca…. Together with @dineshpmcc1 and led by Dakota Gustafson and Priya Mistry, we show that elevated levels of inflammatory and endothelial activation biomarkers before treatment can predict cancer therapy-related cardiac dysfunction.
3
12
2,098
Jason Fish retweeted
So excited to share the first paper from the lab!
We identified CD34 as a marker of the heart’s SAN pacemaker cells enabling their isolation from stem cell differentiation cultures, advancing future disease modeling and biological pacemaker applications.
nature.com/articles/s41467-0…
7
15
43
4,293
Jason Fish retweeted
We're back with another PA Day at UHN! We have two exciting sessions today with students from schools across the GTA coming in to explore #STEM. Stay tuned for some fun snapshots. 💡
2
1
3
449
Jason Fish retweeted
On #WorldDiabetesDay we celebrate the next generation of diabetes researchers - like Cori Lau from @FishLab_UHN. Cori shares why diabetes research matters to him. #WDD2024
3
1
5
449
Jason Fish retweeted
Our next Trainee Lab Seminar Series will take place in-person on Friday, Nov. 15 at 12 p.m. at the Toronto General Hospital. Members from Drs. @TonyKTLam, @FishLab_UHN and Laura Chiavaroli labs will present their latest research. Learn more & register. mailchi.mp/4a1ee55d61ad/bbdc…
1
1
3
489