PhD Candidate & Vanier Scholar @UofT Immunology @EpelmanLab. Macrophages, cardiovascular disease, bioengineering & bioinformatics
Toronto, Ontario
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Very excited to share our latest work focused on hPSC-macrophages in human cardiac microtissue function, now published in @NatureCVR and featured on the cover! (@Ella_Maru) @EpelmanLab
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What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
cell.com/immunity/abstract/S…
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8 years of work. Finally published.
Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1.
Grateful to everyone who made this journey possible. @UHN @UofT_LMP
🔗 ahajournals.org/doi/10.1161/…
#atherosclerosis
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Thrilled to share our latest work, out in @SciImmunology! We show that tissues match their #macrophage numbers to #mitochondrial_activity , ensuring efficient #waste_clearance and #tissue_fitness . A tour de force by Laura Pena-Couso, in collab with @andrsHidalgo16 & Pura Muñoz🧵
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A @UHN @McEwenInstitute team developed the first functional AVN-like pacemaker cells in their new study. 🫀
Their work lays the foundation for the development of a novel treatment that could someday replace the #pacemaker.
🔗 Read more: uhnresearch.ca/news/4-02-202…
@StephIrisPro
ALT Cover image of the Cell Stem Cell research journal depicting an illustration of a heart's conduction system as a highway, and cars driving along the AVN bridge symbolizing electrical signals.
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1/ Can #Axolotls teach us new things about #HeartRegeneration?
A great collaboration between @Tanaxolotl and Miguel Torres lab.
We’re happy to share our new work in which we ask how axolotls regenerate their hearts and could they help mammals with that?
doi.org/10.64898/2025.12.21.…
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Rebuilding human heart tissue. Harnessing #AI for precision care.
@UHN researchers are ‘Pushing the Boundaries of Research’ and redefining what’s possible.
➡️ Discover the innovations shaping the future of health research: uhnresearch.ca/Research-Repo…
#RR25 #DiscoveryToImpact
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Online Now! Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling dlvr.it/TNvxMR #stemcells
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Congrats @Homaira_H for winning best poster at #bcvs2025 @AHAScience. You do @UHN_Research @PMunkCardiacCtr @TBEP_UofT @trogersresearch @CIHR_IRSC proud!
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Abdominal aortic aneurysms are silent killers and a leading cause of death in men over 65.
New research from @UHN’s @TGHRI_UHN uncovers how smoking damages the aorta and activates immune cells that drive rupture, paving the way for new treatments.
🔗 : uhnresearch.ca/news/understa…
ALT Angiography of the abdominal aorta.
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UHN marks the passing of Dr. James Till, whose work with Dr. Ernest McCulloch first demonstrated the existence of blood-forming stem cells in 1961 at Ontario Cancer Institute, now Princess Margaret Cancer Centre.
His work has helped launch the field of #stemcell science.
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Congratulations to Dr. Clinton Robbins and the team at UHN’s @PMunkCardiacCtr on their new study published in @NatImmunol. Their work reveals how cigarette smoke can trigger deadly aortic aneurysms—and points the way to life-saving treatments.
Read more: nature.com/articles/s41590-0…
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Excited to share our review on CAR arming of the innate immune cells. Engineering innate immune cells for cancer immunotherapy | Nature Biotechnology nature.com/articles/s41587-0…
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Now online! Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety dlvr.it/TK6kY4
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Now accepting applications for the Max Planck-Weizmann Joint Postdoctoral Program: • Full four-year fellowship • Advanced research facilities and access to leading experts • Enhance career perspectives • Comprehensive family support.
For more info and to apply >>
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Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
hubs.li/Q037Z29m0
Open stem cell research from Cell Stem Cell.
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What began in 9th grade with a simple question—why do wounds leave angry scars?—has come full circle in the most incredible way. Beyond thrilled to have matched to Plastic Surgery @UofTSurgery @UofT!
It truly takes a village to raise a physician and a community to inspire questions that elevate care. A heartfelt thank you to mine ❤️
Can’t wait for early morning rounds with the dream team @UHN_Surgery again!
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Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration: Immunity cell.com/immunity/fulltext/S…
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Happy New Year! May 2025 be happy, healthy and productive for all.
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Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here, #theonlylabever reports how a gut protozoan commensal microbe remotely shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@CellCellPress ⬇️(1/X)
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So excited to share the first paper from the lab!
We identified CD34 as a marker of the heart’s SAN pacemaker cells enabling their isolation from stem cell differentiation cultures, advancing future disease modeling and biological pacemaker applications.
nature.com/articles/s41467-0…
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