🚨: Nobel Prize physicist Roger Penrose claims there is no such thing as nothingness. Your soul is eternal because matter cannot be destroyed.

HAS ANYONE ASKED THIS BEFORE? What will happen when everyone just vibecodes all the tools they pay for? software becoming abundant will drive demand to 0 for 90% of tools / apps / saas.

Over the last 5 years, I've used every social investing product -- but they all tend to fail in one key spot: Closing the gap between (a) your belief about the world and (b) how to express that belief with stocks. Mike reached out early in the summer and showed me @Supertake, which solves this problem in the most fun way possible: prompt with AI and it constructs a portfolio around your belief. With the declining cost of intelligence, we're going to see much more sophisticated investing styles emerge that was previously reserved only for hedge funds.

falling asleep on planes is a feminine trait what do you mean your brain allows you to let your guard down 35,000 feet above the ground in a compressed tin can with no way out if you feel ‘sleepy’ in this situation then you do not have true warrior blood it’s not time to sleep, we are VERY far from base camp and MUST stay alert

People who drank more coffee had less body fat, less visceral fat, and more lean mass than less-frequent or non-drinkers. The biggest benefit was seen at 5 or more cups per day. And for men, every extra cup per day was associated with a ~10 ng/dL higher total testosterone. Higher coffee intake was also associated with better glucose and insulin regulation in men. This was an observational study, but mechanistic and experimental evidence actually supports coffee's benefits on metabolic and hormonal health. I'm willing to believe there's a real link here rather than draw a conclusion such as "coffee drinkers live healthier lives in general."

How does opus 5.5 have so much usage? Every serious developer is currently running Opus 5.5 24/7 Anthropics servers should be melting but instead Claude is giving out hundreds of dollars in free credits. GTP-6 Astra put so much strain on the OpenAI servers that they shut down the $200 subscription. Anthropic should be in the same position as OpenAI but clearly they have had a technological breakthrough.

Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…

Up to 78 percent of people with ADHD have a body clock that runs late, and moving that clock earlier has been linked to fewer ADHD symptoms. A 2025 paper by two Canadian doctors pulled the evidence together and laid out a treatment plan. Melatonin, the hormone that tells your body it's time to sleep, starts rising about 45 minutes later at night in children with ADHD and about 90 minutes later in adults. Brandon Luu of Queen's University and Nicholas Fabiano of the University of Ottawa gathered this research in Frontiers in Psychiatry. Sleep problems affect up to 80 percent of adults with ADHD and up to 82 percent of children. People with ADHD also tend to have a flatter, later daily cortisol rhythm, and some studies have found a smaller pineal gland, the tiny gland deep in the brain that makes melatonin. Their body clock genes show weaker daily swings too. Melatonin and bright light therapy have both moved the body clock earlier in children and adults with ADHD. Early studies link that shift to fewer ADHD symptoms, and sleep programs for children have improved symptoms, sleep, and daily functioning. Screening every ADHD patient for sleep and body clock problems is the first step in the plan the authors propose. After that come a fixed wake-up time, bright light in the morning, less light and screen time at night, regular daily routines, and low-dose melatonin for people whose clock is clearly running late. The paper is a perspective piece that summarizes earlier research, and much of the treatment evidence is still early. For the large group of people with ADHD whose clocks run late, the first steps it recommends are about light, timing, and routine. pubmed.ncbi.nlm.nih.gov/4145…

Opening access for developers to build Muse connectors. You bring the API -- Muse brings the agent, the browser, and the context of what the person actually wants. People reach your service just by asking for it, and their agent takes it from there. New connectors are live today. Come build with us. muse.ai/platform