Researchers identified how the methyltransferase METTL13 alters the translation factor eEF1A, revealing mechanisms that help drive cancer development and treatment resistance. The findings highlight a potential therapeutic strategy to inhibit KRAS production in tumors. bit.ly/3Wd2KQu

Excited to share our new paper in NSMB! We reveal the architecture of the Norrin signaling complex and use these insights to design synthetic Norrin mimics, taking a step toward developing strategies to restore the BRB. rdcu.be/DZdju6tDqpPa

St. Jude scientists identified ZMYND8 as a major regulator of CD8+ T-cell exhaustion. Targeting the gene improved immune function and enhanced immunotherapy, offering a potential new strategy to strengthen anti-tumor responses in solid tumors. bit.ly/3TiiMrc

Nature research paper: Transcriptional activation of plant immunity by salicylic acid go.nature.com/4iwMwe9

St. Jude has named Charles W.M. Roberts, MD, PhD, internationally recognized physician-scientist and director of the St. Jude Comprehensive Cancer Center, as its seventh president and CEO. The announcement is part of a planned leadership transition. Under his leadership, the Cancer Center has grown in scope and impact, earning the National Cancer Institute’s top “Exceptional” rating in both reviews and the best score in institutional history each time. Dr. Roberts’ background in cancer epigenetics, clinical care and collaborative leadership has helped shape major efforts that connect researchers, clinicians and partner institutions to move discovery forward.

Scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. ow.ly/Yk9N50YxEXN

Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. rdcu.be/e3waV

My lab #NUS is located at the place near the arrow. My daily walk to the lab feels like stepping into the applewood Wardrobe in Narnia.

Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating nature.com/articles/s41422-0…

A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience pnas.org/doi/10.1073/pnas.24…

Congratulations, Hongbo!!!

Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. ow.ly/77Yl50VGpKe

Congratulations 🎉, @JunminPengLab

Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy go.nature.com/41AWsZX

Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab nature.com/articles/s41586-0…

Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s41467-0… @JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers

Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. nature.com/articles/s41586-0…; nature.com/articles/s41586-0…

Interesting work from @TheHurleyLab

Congratulations, Chunyi!

congratulations, Christoph.