Project Lead - Senior Staff Scientist at the Chan Zuckerberg Biohub (@czbiohub).
San Francisco, CA
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We recently launched zebrahub.org a resource for exploring the complexities of #zebrafish #development with #scRNAseq and #lightsheet.
As #biology enters the era of big-data, we're excited to make navigating it easier. Come explore with us
biorxiv.org/content/10.1101/…
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Merlin Lange retweeted
So excited to start the year w/ our new paper @CellCellPress! #proteomics spatial map of human cells + dynamics using #organelle IP at scale. 🙌 to amazing teamwork @czbiohub and beyond. Check out portal organelles.czbiohub.org and paper cell.com/cell/fulltext/S0092…. 1/n
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Merlin Lange retweeted
I am excited to join the next cohort of Allen Distinguished Investigators and looking forward to parsing the role of organelle interactions with imaging and AI in partnership with @cohenlaboratory and @AssafZaritsky!
How do organelles change over the course of a stem cell’s life?
@cohenlaboratory, @AssafZaritsky, and @mattersOfLight are using machine learning and cell engineering to study the impact of organelle-organelle interactions on stem cell differentiation. #FrontierScience
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Merlin Lange retweeted
Having a blast at #MetabolismInAction2024 and thanks @nigrelex for your awesome science illustrations!
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Merlin Lange retweeted
Individuality is fascinating. Check how to quantify variability among individuals by identifying long motor strategies during navigation on small 🐟! Check the latest @wyartlab work from Dr. Gautam Sridhar & @antoniocbscosta @InstitutCerveau @PNASNews: pnas.org/doi/10.1073/pnas.24…
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Very impressive! Congrats to all the team
Today in @NatureBiotech we report on the use of base and prime editing for high throughput interrogation of genetic variants in cancer. Excellent work by first authors @olivier_belli & @k_karava. 🧵👇
tinyurl.com/2js9dwyp
@ETH_en @ETH_BSSE
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Merlin Lange retweeted
🦓 Introducing #Zebrahub: a new #zebrafish developmental atlas from Drs. @Merlin_Lange, @LoicARoyer, and a team at the @CZbiohub!
Check out the @CellCellPress paper: bit.ly/3UtCmOu
Listen to the discussion on this week's episode: bit.ly/4f30gJ1
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Merlin Lange retweeted
We’re thrilled to announce that registration is now open for the 6th edition (on March 2025) of the Paris School on All-Optical Neuronal Circuits Control with Optogeentics and Multiphoton Microscopy!
Join us and explore the latest breakthroughs with an outstanding lineup of experts covering cutting-edge techniques and hands-on practical demonstrations @3i_inc @dim_elicit on: holographic light shaping, 1P and 2P optogenetics @ClaireWyart @zenith_etn and voltage imaging @MichaelLinLab, 2P mini-scopes @WikiZong, 2P fiber-based endoscopy @NicsNextTo, 3P microscopy, 2P holographic mesoscopy @LamiaeAdm @AdenisikHillel, viral expression strategies @DalkaraLab, pioneering genetic tools @joH_VieR @OferYizhar , new approaches for high throughput connectivity mapping @DimitriiTanese @ChenIWen1 @koweiss .
More details at vdesars.github.io
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Merlin Lange retweeted
These are the nuclei of individual cells, tracked with precision as they move throughout development in a zebrafish embryo.
Captured thanks to custom-built microscopes + analysis tools made by @Merlin_Lange, @LoicARoyer + team at the #CZBiohubSF 🤩 czi.co/48hwsWe
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Merlin Lange retweeted
Using an embryo-model to study Hoxb13 regulation and its impact on tail growth. Now @PNASNews 🙏Lucille, Joska, Celia, Hocine et al👍@EPFL @UNIGEnews @cdf1530 @the_Node #InHoxWeTrust
pnas.org/doi/epdf/10.1073/pn…
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Merlin Lange retweeted
🎓 Join us for our Spring School in Quantitative Biology: "Cell Dynamics in Developmental Systems"
✨ Featuring renowned speakers and hands-on workshops!
Learn more and register: edu.bio.ens.psl.eu/spip.php?…
#QuantBio #DevBio #QLife @ParisSciencesLet #PSLuniversity
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Merlin Lange retweeted
📢We have a 3y postdoc position available in our interdisciplinary team
@institut_curie #Paris
Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics.
institut-curie.org/team/bell…
Please RT!
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Very normal day at the microscope with @loicaroyer 😄
#zebrahub
Understanding how a single cell develops into an entire body is one of biology’s biggest mysteries. Today we celebrate @Merlin_Lange + @loicaroyer & the team at #CZBiohubSF for publishing Zebrahub, a resource that gets us closer to solving this puzzle 🎉
czi.co/48hwsWe
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Merlin Lange retweeted
Now online! A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors dlvr.it/TFm4z1
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Merlin Lange retweeted
Understanding how a single cell develops into an entire body is one of biology’s biggest mysteries. New in @CellCellPress: #Zebrahub, a “Google Earth” of embryology, is helping crack the code.
Read➡️
czbiohub.org/life-science/ze…
🎥 @loicaroyer & @merlin_lange of #CZBiohubSF explain:
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Thrilled to share this milestone! Zebrahub atlas live in #Cell. A powerful fusion of #scRNAseq and #lightsheet imaging to map zebrafish development in real-time.
Exciting step towards decoding embryogenesis! 🐟 🔬🧬#zebrafish #imaging #developmentalbiology
🚨Big news! Five years in the making, our Zebrahub paper is now published in #Cell 🎉. We’ve built a timecourse atlas of zebrafish embryonic development, combining #scRNAseq data and #lightsheet live imaging, and delved deep into the dynamics of key progenitors.
cell.com/cell/fulltext/S0092…
Explore the datasets here:
zebrahub.sf.czbiohub.org
Led by @Merlin_Lange with key contributions by @ale_agranados, @Shruthi94Vijay, @jobragantini, @Sarah_E_Ancheta and @yangjoonkim
#zebrahub #devbio #cell #Biology #imaging @CellCellPress @czbbiohub #CZBiohubS
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Thrilled to share our new "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis"! 🐟 doi.org/10.1101/2024.10.18.6…
Great effort lead by @yangjoonkim. Check out @loicaroyer thread 👇and explore the interactive ressource zebrahub.sf.czbiohub.org/epi…
📡🧵 Excited to release two #bioRxiv preprints!
The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis"
doi.org/10.1101/2024.10.18.6…
We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf).
A major accomplishment by @yangjoonkim co-led by @Merlin_Lange with experiments by @Shruthi94Vijay #Zebrahub-Multiome is a sequel to zebrahub.org, our transcriptomic and imaging atlas of zebrafish development.
#zebrafish #development #ATACseq #cell #biology #sequencing @czbiohub #CZBiohubSF @cziscience
Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...
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Merlin Lange retweeted
Whistle variability and social acoustic interactions in bottlenose dolphins biorxiv.org/content/10.1101/…
This is a dream came true. Our first manuscript on dolphin communication is out.
This is the work of Faadil and Chiara, in collaboration with @dePolavieja
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So happy that our protocol paper which optimizes obtaining great quality single cells from a single Zebrafish embryo is finally out!
Thanks a lot @Merlin_Lange @loicaroyer @mikeborjatweets for all the help!!😊
sciencedirect.com/science/ar…
Our application : zebrahub.sf.czbiohub.org/
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