Excited to share a milestone in our forward genetics developments! Today in @Nature we report massive mutagenesis screening in T cells with base editors, increasing resolution from genes to nucleotides nature.com/articles/s41586-0… A @MarsonLab story with my dear friend @carlcward 1/10

Really great to see this important work published. Congrats @LaineGoudy @LukeGilbertSF!!

So excited to see our work on the TCR adapter TRAT1 finally published in Cell Communication and Signaling! Congrats to Tobias Frey and thanks to all Lab members and collaboration partners involved! biosignaling.biomedcentral.c…

Multi-layered CRISPR screens converge on RHOG +/- FAS for enhanced CAR T cell therapies. Impressive work from Vienna - Congrats @BockLab and collaborators!

🧬 CAR T cells demonstrate the power of engineered cells as therapeutics. But they fail for most patients. Can we make them better by gene editing? Our paper in @Nature presents a CRISPR platform for optimizing immunotherapies & discovering boosters of CAR T cell function. (1/13)

🚨New paper alert! 🚨 Our latest work in @ImmunityCP shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/ar…

We have another opening for a fully funded PhD position in the Beusch lab (beuschlab.org) @Uni_WUE! If you or someone you know is curious about #splicing, please apply or feel free to contact me for more information. (Official advertisement tba soon.)

Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in @Nature thanks to the work of many! nature.com/articles/s41586-0…

🧬CRISPR TREND: we get so excited about CRISPR for C&GT & in-vivo reprogramming we forget what a powerful tool it can be for screening. You are about to witness some super interesting target discovery innovation where individual cell types are interrogated at scale.

🗨️ WANNA TALK TO YOUR CELLS? Try out CellWhisperer – our new multimodal AI that turns single-cell RNA-seq analysis into a conversation. No coding needed, just chat in plain English. Short walkthrough below. Web app & bioRxiv preprint linked in the thread. Let's dive in! (1/9)

Possibly the biggest single experiment we’ve done in the lab! @ardinyo_ and @XanWesolowski have been working round the clock! Genome wide CRISPR screen in 1e9 primary lymphocytes!

Happy to see this project being published 🎉🥂thank you to everybody involved ! I’m very much looking forward to future applications of our LZTR1 screening assay and potential novel discoveries 🤞🤞🤞

Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering. Read the full article by @FraunhoferIZI Sandy Tretbar et al. in @MolTherapy #ASCO24 hubs.li/Q02yvDVx0

Very happy to share some of my PhD work, published yesterday in @NatureBiotech. Especially thankful for truly exceptional mentorship from my PI, @BizarMd, who encouraged me to leverage powerful gene editing tools to ask some exciting questions bridging immunology and genetics

After 𝘻𝘦𝘵𝘢, here comes 𝘦𝘱𝘴𝘪𝘭𝘰𝘯 🥳: We present CD3ε gene editing as a GMP-compatible strategy uniquely suited to create potent Tregs with redirected antigen specificity for adoptive cell therapy. #Treg #CARTreg #EUhorizon2020 #ReSHAPE biorxiv.org/content/10.1101/…

I am really excited to share with you my PhD work in @bsadamson lab. A huge thanks to all Adamson Lab members, our collaborators, and @Nature. This project wouldn’t be possible without you.

Check out the latest generation of prime editors! Also works in primary human T cells (Figure 5). Awesome work by @juuuuunay and @bsadamson. Thanks for including us in this great story.

Check out this great opportunity to become part of a highly collaborative team aiming to turn fundamental T cell genomics into meaningful therapies.

This is incredibly enabling and will accelerate so many science endeavors. Congrats on the great work!

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology. PDF: drive.google.com/file/d/18hu… 1/13

Excited to share our early phase 1 results for bivalent #CARTcells in recurrent #glioblastoma. Now online @NatureMedicine. Awesome team effort! @PennMedicine @PennCancer @PennNSG @DrORourke2 nature.com/articles/s41591-0…