Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch
Memphis, TN
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We end the symposium with closing remarks by Madan Babu @m_madan_babu.
We thank all speakers and session chairs, and hope all participants enjoyed the exciting science and stimulating discussion. We look forward to continuing the conversation at the reception tonight and beyond!
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Very excited about the Keynote Lecture by Rod MacKinnon from @RockefellerUniv and HHMI, introduced by former mentee Chia-Hsueh Lee @TheCHLeeLab
The auditorium is jam packed!
#ionchannel #membrane signaling
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Session on #microbes and #pathogens, with more spectacular #CryoEM and #CryoET!
We have Susan Lea @S_M_Lea and the bacterial flagellum, and Mimi Ho @mimi1inh on an integrated approach to understand the native translation machinery in situ in #malaria parasites.
#molecularmachines
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We are starting our 3rd Structural and Computational Biology Symposium!
Babis Kalodimos @KalodimosLab opens the event, followed by a session on structural cell biology chaired by Yiorgo Skiniotis, with Abhay Kotecha @AbhayKot and Shyamal Mosalaganti @s_mosalaganti #CryoET
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All ready for our upcoming symposium here at St. Jude. We have a stellar lineup of speakers and over 250 registered attendees!
Looking forward to two days of exciting science!
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We are thrilled to welcome the incomparable Yiorgo Skiniotis and his lab!
Yiorgo will also lead the new Center of Excellence for Structural Cell Biology, to advance cryoET and other cutting-edge approaches @StJudeResearch, paving the way for new, exciting biological insights!
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We are happy to announce the public release of EMhub, a web platform designed to support the operations of a scientific facility, enabling easy management of users, instruments, bookings, and project tracking. EMhub was unveiled at the #ACA2024 last week by @delarosatrevin
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Out today in @NaturePhysics, exciting work from @TanjaMittag in collaboration with @PappulabWashU and @BanerjeeLab_UB reveals how amino acid sequence determines the viscoelastic properties and physical aging of biomolecular condensates. nature.com/articles/s41567-0…
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Must-read work from @TheBlanchardLab in @naturemethods today!
#FRET efficiencies from commonly used fluorophores decrease at high illumination intensities, due to the accumulation of "dark" triplet states.
#open
nature.com/articles/s41592-0…
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Exciting work from @TheCHLeeLab with @mjafreeman out in @MolecularCell reveals the multilayered roles of pseudoprotease iRhom2 in the maturation and regulation of #sheddase ADAM17.
#cryoEM #openaccess
cell.com/molecular-cell/full…
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In @NatureComms, the @JiSunLab integrates #cryoEM, MD sims and mutagenesis to reveal how calcium binding activates the human NOX5 enzyme, with insights into how NADPH oxidases catalyze electron transfer from NADPH to FAD to produce #superoxide
nature.com/articles/s41467-0…
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From @JiSunLab, @zhu_hanwen, Martin Turk & Dario Alessi's team @mrcppu, #cryoEM structures of LRRK2–Rab29, including tetrameric assembly with central protomers in sought-after kinase-active conformation — implications for #Parkinsons disease therapeutics
science.org/doi/10.1126/scie…
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A #GPCR milestone from @m_madan_babu & @fmheydenreich, with Kobilka @stanford @Michel_Bouvier. Integrating pharmacological and structural data on beta2AR reveals the allosteric network that translates and decodes adrenaline binding into signaling response.
science.org/doi/10.1126/scie…
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Another gem from @TheCHLeeLab out @Nature offers mechanistic insights into human VMAT2 — transporter that packs monoamine neurotransmitters into vesicles — including on MOA of inhibitors tetrabenazine and reserpine and transport of substrate serotonine.
nature.com/articles/s41586-0…
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Looking forward to the Keynote Lecture by Richard Henderson @MRC_LMB, with introduction by @m_madan_babu — the auditorium is packed! #cryoEM
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166 fusion oncoproteins were systematically assessed for their ability to form condensates in cells. The data were then used to develop a ML-based tool that predicts condensation behavior of other fusion oncoproteins, based on physicochemical features from their sequences.
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We are excited about the upcoming 2nd Structural and Computational Symposium, an in-person-only forum for open scientific exchange, with a diverse range of voices and perspectives.
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Variant accessibility is shaped by the mutational biases during replication and the genetic code structure. Using the #influenza A virus as a model, they discuss how a more accessible but less fit variant can emerge as an adaptation, rather than a more fit variant. #evolution
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A genotype accessibility landscape informs on the likelihood of a starting sequence to reach different parts of the genotype space and complements the genotype fitness landscape.
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We have exciting news to share: the one-and-only Liz Kellogg is joining our department as Associate Member this summer!!!
We look forward to welcoming @kellogg_liz and her awesome team — @theREALJeffSwan @JungUn_Park @vinhbiochem @SchargelRichard & James Borovilas— to Memphis.
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Our search for new faculty members is still open — deadline for applications is July 1st!
talent.stjude.org/careers/jo…
To learn about the exciting research and incomparable resources in our department:
stjude.org/research/departme…
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Spns2 is a potential therapeutic target in inflammatory and autoimmune diseases, and the work captures multiple conformation states during the transport cycle, as well as an inhibitor-bound form.
Congrats to @shah_med, Hongwen Chen, @HongtuZhao and all coauthors!
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Let us celebrate the election of M. Madan Babu as Fellow of the @royalsociety!
Congratulations, Madan, we are so proud of you!
royalsociety.org/news/2023/0…
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We are hiring new faculty members:
talent.stjude.org/careers/jo…
Our state-of-the-art Technology Core Centers, staffed by expert scientists, empower integrative structural biology.
stjude.org/research/departme…
please RT!!
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We are looking for new faculty members who want to pursue bold and creative science in an open, collaborative environment.
Applicants in all areas of #biophysics and #structuralbiology are welcome. Come join our exceptional faculty!
talent.stjude.org/careers/jo…
Please RT
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Work from Schulman lab @MPI_Biochem and @StJudeResearch out @CellCellPress shows how CAND1 promotes exchange of F-box proteins in idle SCFs to recycle CUL1 and reveals a new paradigm for remodeling the cellular repertoire of multicomponent complexes. #OA
tinyurl.com/bdnz25d6
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Now #OA @Nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, @TheBlanchardLab reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors.
nature.com/articles/s41586-0…
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From @TheBlanchardLab and @ChenLabRU out @Nature:
integrating #singlemolecule #FRET #ephys reveals how CFTR gating is regulated by NBD dimerization and ATP hydrolysis, and mechanistic insights into potentiators and disease mutations
nature.com/articles/s41586-0…
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And here is our cover image submission — peeling back the layers of complexity in SPOP function and dysregulation. Concept and artwork by @NormanLuo5
From @TanjaMittag lab: Matt Cuneo, @boflynn_SJ et al use #cryoEM to examine the filament assembly of full-length SPOP, revealing novel domain and protomer interaction interfaces that include positions bearing GOF mutations in endometrial cancer.
cell.com/molecular-cell/full…
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From @HalicLab: nucleosphosmin-like Fkbp39 promotes dissociation of nascent ribosomes from chromatin and drives their movement through the nucleolus as they mature and assemble. #cryoEM #LLPS
cell.com/molecular-cell/full…
Featured on the cover @MolecularCell, artwork by @NormanLuo5
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Work from @JunminPengLab in @NatureAging demonstrates causal link between U1 snRNP dysfunction and neurodegeneration in #AlzheimersDisease, using proteomics, transcriptomics, histopathology, electrophysiology & behavioral studies with new #mousemodel:
rdcu.be/cXsTQ
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Check out postdoc salaries, benefits, and support at St. Jude:
stjude.org/education-trainin…
Postdoc positions currently open in Structural Biology include:
talent.stjude.org/postdoc/jo…
talent.stjude.org/postdoc/jo…
talent.stjude.org/postdoc/jo…
Come join us!
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Work from @LabHalic with @StefanCanzar now @NAR_Open.
Using genome-wide approaches to dissect the pathways that lead to #heterochromatin silencing, they unveil a new mechanism — decreased transcription efficiency, in a pathway that requires CCR4–NOT.
academic.oup.com/nar/advance…
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Beautiful work from @TheCHLeeLab in collaboration with Lily Jan's group @UCSF is now out #OpenAccess @MolecularCell.
The human Kv4 is captured in 4 different conformations, including a resting state and the first view of the closed-inactivated state!
cell.com/molecular-cell/full…
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We look forward to welcoming our guest speakers in person at St. Jude next Monday for the Symposium!
#structuralbiology #crystallography #NMR #cryoEM #cryoET #MDSims #HybridMethods #MachineLearning #ComputationalStructuralBiology #IntegrativeStructuralBiology
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Work from @TheBlanchardLab and @WilsonLab2 combines #smFRET and #cryoEM to reveal the mechanism of action of antimicrobial peptide argyrin: ArgB binds EF-G on ribosome and inhibits conformational changes required for translocation and EF-G dissociation.
pnas.org/doi/full/10.1073/pn…
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Learn about the power of smFRET and our Single-Molecule Imaging Center @TheBlanchardLab in this cool animation:
piped.video/watch?v=4aF36-Qe…
#smFRET #StJude
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Work from @MoldoveanuLab now out @NatureComms determines the structural basis of BAK autoactivation and shows the cooperation of autoactivation and direct activation in the apoptotic response.
Congrats to all the authors!
nature.com/articles/s41467-0…
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Now out @NatureChemistry: work from @TanjaMittag lab in collaboration with @PappulabWashU deciphers the rules in the stickers-and-spacers model that govern phase separation by prion-like low-complexity domains.
nature.com/articles/s41557-0…
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Out in @CD_AACR: by integrating biophysics, cellular imaging and transcriptomics, Kriwacki, Mullighan & colleagues demonstrate the role of LLPS in leukemogenesis by NUP98 fusion oncoproteins and identify the specific molecular interactions involved.
cancerdiscovery.aacrjournals…
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Our heartfelt congratulations to Tanja Mittag for becoming a Full Member @StJudeResearch!
Since joining our department in 2010, @TanjaMittag has made seminal contributions to the #LLPS field, rigorously integrating different approaches to answer fundamental biological questions.
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Just out @nature from @KalodimosLab
Integrative structural biology reveals the mechanism of ligand-induced activation of ALK — reorientation of the extracellular region of ALK promotes its dimerization.
nature.com/articles/s41586-0…
Animation by @NormanLuo5
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We are delighted to announce that Israel Fernandez will soon join our department as Director of the Cryo-EM Center. Welcome to St Jude, @IsraelF96135088!
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Work from @TanjaMittag @ewmartin et al. now out @NatureComms!
Combining rapid mixing with time-resolved SAXS, they examine the earliest events in phase separation and analyze kinetics of nucleation.
Check it out here:
nature.com/articles/s41467-0…
#phaseseparation #OpenAccess
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Mutations in LRKK2 are implicated in Parkinson's disease. #cryoEM structures of human LRRK2 reveal its architecture and provide a blueprint to understand regulation and disease mutations.
@CellCellPress: shorturl.at/gFGJR
Congrats @JiSunLab et al.!
Artwork by Zhaowen Luo
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Work from @TheCHLeeLab presenting #cryoEM structures of the human serine palmitoyltransferase holocomplex, now featured on the cover of NSMB!
Article here: nature.com/articles/s41594-0…
Also highlighted in N&V from Binks Wattenberg @VCU: nature.com/articles/s41594-0…
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Now in @naturemethods: detecting and tracking GPCRs on the surface of live cells with smFRET. A long-standing collaboration between @TheBlanchardLab and the Javitch lab @ColumbiaPsych, congratulations to all!
nature.com/articles/s41592-0…
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We are very excited to announce that Madan Babu, currently a Programme Leader at @MRC_LMB, will be joining our department next month to lead our efforts in Data Driven Discovery. @StJudeResearch
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Congratulations to Kriwacki lab@kriwacki and collaborators on this great work @nature exploring thermodynamics for phase separation. nature.com/articles/s41586-0… #StructuralBiology#phaseseparation
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