One year of APA+ADT comes with toxicity, and outcomes after control-arm salvage aren't shown. His view: follow-up too short; would not yet support perioperative APA+ADT with RP in high-risk disease, needing mature survival and post-salvage data first.

#ESMO26 PROTEUS discussion by Nicholas van As • No baseline PSMA PET; enrolled conventionally staged M0 • MFS events: true progression or delayed detection? Most were PSMA PET-detected (8.8% vs 16.3%) • TTST HR 0.29, but ~20-mo lead-time bias #ProstateCancer

Freddie has been officially immortalized. He will always be remembered for his vision, commitment, and passion in working with Jenny Donovan and the rest of the ProtecT team to forever change the way we think about men affected by prostate cancer. I remain deeply saddened to learn he has pancreatic cancer, yet so happy he’s still doing well 5 years after the diagnosis. @QuinteTBristol @NehaVapiwala @TylerSbrt

#ASTRO26 @nickva1 presents 5 yr data of PACE-A: SBRT v RP no differences in clinical outcomes use of =1 urinary pad 8.3% SBRT V 48% RP Low GI/GU events <%4 each arms

@nickva1 @royalmarsdenNHS presenting 5 year outcomes of PACE-A @EmmaHall71 Surprised to see numerically less bowel bother in the SBRT arm, noting small numbers. Await sexual outcome data tomorrow @ASTRO_org #ASTRO26

I would call that a massive difference in clinical outcomes! (I know what you mean though!)

#ASTRO26 Plenary -- PACE-A: 5-yr Outcomes of RP vs SBRT for GG1-2 PCa @nickva1 @urotoday 📍n=123 (60 RP, 63 SBRT), mFU 8 yrs, 10 🇬🇧 centers 📍13 BCF events: HR 0.48, 95% CI 0:16-1.46 📍7 deaths (no PCa): HR 0.55, 95% CI 0.12, 2.46 📍EPIC-26 >=1 urinary pad: 14/29 (48%) RP vs 3/36 (8%) SBRT 📍EPIC-26 bowel bother: 1/28 (4%) RP vs 0 SBRT

#ASTRO26: PACE-A showed 8-year biochemical/clinical failure-free rates of 91% with SBRT vs 84% with prostatectomy, although the difference was not statistically significant. SBRT also showed less urinary incontinence at 5 years. @nickva1 urologytimes.com/view/sbrt-p…

#ASTRO26 @ASTRO_org Plennary session II #SBRT #ProstateCancer #PaceB @nickva1 Time of change

Hi friends, it's #ProstateCancer Friday! Here are Top Posts of the Week 🧵 1/ @nickva1 on the recent @EUplatinum focal therapy paper:

Really important trial, and great to see 202 pts recruited. Well done!!

Please see our letter @alison_tree @piet_ost in response to the recent Focal therapy paper in @EUplatinum authors.elsevier.com/a/1nlq2… @LondonProstate1 @mrsprostate @taimurShah @ASTRO_org @ESTRO_RT

💬 What do patients say about their long term quality of life after prostate radiotherapy? Find out from the practice-changing PACE-B trial here 👉 doi.org/10.1016/j.eururo.202…

10 billion will buy some lovely horses 😊

Great data!

Great study @alison_tree and lovely presentation @DrSACooper