🔔After it being a LONG time in the works, today we launch "Applied Nutrition Literacy", a course that Dr. Alan Flanagan and I have developed. 📊The goal: To help you become competent and confident in your critical appraisal of nutrition research. See: nutritionliteracy.podia.com/

New episode: Prof. @h_sokol discusses: - the fascinating work looking at microbiome-drug interactions - the potential for bacteria as a drug - the problems of over-hyping changes in the microbiome as evidence of benefit 🔗sigmanutrition.com/podcast/e…

For podcast listeners seriously into health, fitness, and nutrition, @BarbellMedicine with the outstanding @Jordan_theCoach and @AustinBaraki and @sigma_nutrition with the always thoughtful @NutritionDanny are must listens. Some other great stuff out there in a vast sea of junk but these two pods are truly top notch.

KETO-CTA is a case study, not because of results, but communication. There’s no going back.

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There is so much noise around testosterone levels, testing, & TRT. But how should test results actually be interpreted? And what cases would likely benefit or not from treatment? @AustinBaraki expertly discusses all this and more in the latest episode: sigmanutrition.com/podcast/e…

This isn't hard to understand. Nick probably makes 5-10x (or more?) as much money as he would as a medical intern, and gets 1000x as much praise, clout, etc. Great for the bank account & ego, while not having to go through any of the experiences that make you a doctor.

Popular science communicator/researcher: “for every 5 grams of fiber you're going to reduce your overall risk of mortality by about 14%” "... so increasing from 15g to 20g will give you this improvement in your lifespan" This is an error. Article: linkedin.com/pulse/those-ras…

If someone already eats a high-quality diet without fish, would adding it make that diet healthier? The answer may depend less on fish in isolation and more on the overall diet and the food being replaced. New episode: sigmanutrition.com/podcast/e…

How wellness & optimisation culture can commodify science. New episode w/ @NBTiller sigmanutrition.com/podcast/e…

Recently @AlyshaThompson1 & her colleagues published a study looking at whether UPF content influences the relationship between plant-based diets & disease/mortality risk, once we account for diet quality. Here I discuss the study with Dr. Thompson: sigmanutrition.com/podcast/e…

Huberman is on the board of / advises / is sponsored by @function, who sell full body MRI scans at $3999 per their website. Keep this in mind given the very likely fake story of his neurosurgeon friends operating every month based on incidental findings.

I agree with Sam - this is really big news and should quite the inflammation first crowd - Back to first focusing on lipids and lipoproteins @nationallipid @society_eas @ASPCardio @escardio @atherosociety

Dave himself at 1:38:55- "For decades, modern medicine has assumed high cholesterol on a low carb diet is dangerous for everyone. Today new data is showing us that the story is much more nuanced, offering new hope to countless people who rely on keto for their health." “New hope”… Let’s remember this documentary was made while they had a retracted paper and a pre-print that hadn’t been peer-reviewed. I think most people would have a better taste in their mouth if this was less marketing and story-telling and more science.

I read every word of this, unfortunately. It is a mix of admitting to embarrassing but not fatal errors/dishonesty for which there is a smoking gun and many thousands of words of hand waiving about more disqualifying elements. It is hard to conclude that Dave and his “team” are doing anything except trying to extend the lifespan of this narrative as long as possible (and based on the coverage they’ve gotten from actual doctors in medium-circulation podcasts, it’s working, unfortunately). Also, the notion that you would upload a pre-print that is a first draft that includes figures that depict malicious deception is bullshit. Don’t fall for it.

So sneaky. "induce remission in treatment-resistant inflammatory bowel disease (IBD), including Colitis and Crohn's disease. (PMID: 37967555)" The study referenced is a mouse model. It does not demonstrate disease remission in humans, who [presumably] this video is aimed at.

I’m totally disappointed by the radio silence on this from @realDaveFeldman and @nicknorwitz who claim to be genuinely interested in science - no matter the findings. If @realDaveFeldman and @nicknorwitz are good faith operators they will respond to this detailed criticism of their pre-print. If we do not hear from them and they continue to promote their documentary… I’ll leave you to speculate on what that suggests. The Science behind The Cholesterol Code piped.video/wE0BQDc_6dY?is=TuG-… via @YouTube

This will be an interesting one! 🤓

In the latest episode, we take a look at unprocessed red meat intake and colorectal cancer risk. With a specific focus on controlled trials looking at mechanistic biomarkers related to colorectal carcinogenesis. Enjoy! sigmanutrition.com/podcast/e…

Hi Dave — thank you for the kind words on our NATURE-CT publication. You asked a fair question: how would Keto-CTA look if we only looked at the people with CAC ≤ 100, just like we did in NATURE-CT? Any comparison using the original KETO-CTA data is no longer valid. The paper was formally retracted by JACC Advances at the authors’ own request. The retraction notice is here: jacc.org/doi/10.1016/j.jacad… Even setting the retraction aside, the plaque progression rates in the keto/LMHR group were much higher than the healthy rates we reported in NATURE-CT: ~18.9 mm³ median NCPV increase vs ~4.9 mm³ annualized in NATURE-CT. This faster plaque progression is the adverse effect directly linked to the very high ApoB/LDL-C levels caused by the keto diet. The public should be warned that this is likely a dangerous approach, especially for those who show rapid plaque progression as defined by OUR study. Standard of care guidelines from the ACC and AHA recommend lowering ApoB and LDL-C to reduce heart disease risk. They advise against allowing sustained high levels like those seen in keto dieters. Caution is essential. We can now define and treat rapid progressors even before calcium is present, as documented in our First-in-Human paper: jacc.org/doi/10.1016/j.jacca… This is further supported by performing serial imaging—an approach we first described in 2013 in Atherosclerosis: atherosclerosis-journal.com/… We subsequently confirmed this over 13 years using current technology in our 2022 paper on serial analysis of coronary artery disease progression by AI-assisted coronary CT angiography: pubmed.ncbi.nlm.nih.gov/3643… We all agree that baseline plaque strongly predicts future plaque. But decades of research also show that sustained high ApoB/LDL-C drives atherosclerosis progression. In this group who chose the keto diet often against "standard of evidence advise", close lipid monitoring and careful risk assessment are essential. Keto is likely harmful to arteries for most people, even if some tolerate it well. Looking forward to continuing open discussion. Best Ron Karlsberg MD FACP FAHA FACC MSCCT (Lead author, NATURE-CT)@realDaveFeldman @DLBHATTMD @MichaelAlbertMD @CMichaelGibson @RonBlankstein @chamath @ethanjweiss

I suspect the reason for going on and on about this case study is to deflect attention away from their preprint. The QAngio results reveal most participants had detectable plaque, median plaque increased, and 21% met a significant progression threshold. Leaving aside severe methodological limitations, those results don't support the documentary's main claims, so all this seems like a desperate attempt at reframing around a single case. And as seems typical of this group, the tables with the clear interpretative results are buried in the supplementary materials.