Professor of Biomedical Engineering at Duke University, Director of the Center for Advanced Genomic Technologies
- Tweets 155
- Following 120
- Followers 1,406
- Likes 117
Pinned Tweet
We're very excited to launch of the Duke Center for Advanced Genomic Technologies @DukeCAGT, a joint venture of @DukeEngineering @DukeMedSchool and @DukeTrinity. We are supporting collaborative research efforts to tackle grand challenges in genome sciences and engineering.
2
12
53
We propose remaining challenges and opportunities for epigenome editing, and provide a future outlook. We are incredibly enthusiastic about the pace of new technology development in this area, the fundamental discoveries it is enabling, and what it can do for patients!
1
2
867
Epigenome editing is transforming biological sciences and medicine. We're grateful for the opportunity to publish this review of the field in @NatureBiotech. Check it out here: rdcu.be/dPjsJ
10
67
274
44,726
Epigenetic control is incredibly powerful for bolstering cell therapy. We’re very excited to continue to build on the foundation established with this publication.
Scientists have engineered a modified CRISPR technology targeting the epigenome capable of modulating T-cell behavior. In the process, they discovered a master regulator of the genome that reprograms T cells and enhances their cancer cell-killing ability. ow.ly/opgC50Q8lq0
8
24
4,184
Charles Gersbach retweeted
Using a new CRISPR-based methodology, a team of researchers led by @cgersbach @DukeU has identified a “master regulator” gene capable of dramatically improving T-cell therapy performance >>> bit.ly/47vsnwN
3
3
581
Charles Gersbach retweeted
Epigenetic CRISPR screening in human T cells reveals that BATF3 overexpression enhances T cell function, reduces exhaustion, and boosts CAR T cell potency in both in vitro and in vivo tumor models. #NBThighlight nature.com/articles/s41588-0…
2
55
193
36,744
Very happy to share our latest work today in @NatureGenet - "Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens" - led by @DukeUBME PhD student Sean McCutcheon. 1/n
nature.com/articles/s41588-0…
rdcu.be/dqHFO
6
20
147
17,583
This is our first report of a broader active area within our research group on T cell engineering. We are excited to repurpose the tools and protocols developed here for improve ACT and CAR-T for diverse applications. We’re looking forward to sharing more on these efforts soon!
1
1
455
We are incredibly thankful to our collaborators and co-authors, and our funding sources for supporting this new research direction! @somaticediting @ENCODE_NIH @IGVFConsortium @genome_gov @NSF @AllenInstitute @DukeU @DukeCAGT
2
441
Looking forward to a great meeting!
FGE23 @bitsgoa is less than a week away and the whole team @IGIBSocial is excited to welcome guests and participants from all over the world! @BKleinstiver @palermo_lab @randall_platt @cgersbach @AngelaEGGLEST17 @XueSherryGao @Ajit_IISER @MohankumarKMur1 @WeixinT @KomorLab
3
889